Factors that Influence the Way Communities Respond to Proposals for Major Changes to Local Emergency Services: A Qualitative Study

According to policy commentators, decisions about how best to organise care involve trade-offs between factors relating to care quality, workforce, cost, and patient access. In England, proposed changes such as Emergency Department closures often face public opposition. This study examined the way communities respond to plans aimed at reorganising emergency services, including the trade-offs inherent in such decisions

A transputer Based Laser Scanning System

This paper presents a transputer-based laser scanner. This is to be integrated into an existing transputer-based mariufacturing environment to allow rapid construction of' 3-0 models. The approach allows Z-gradient informaticm to be obtained from a 2-D image by illuminating areas of interest with a form of structured light. An active scanning system is described. Simple algorithms are applied to the raw image data to extract concise information. This foveal analysis greatly reduces the data to be processed, allowing a simple and fast method for analysis. The system primarily consists of a video camera wlhich obliquely views a scene being scanned by a laser. The principle, the procedure, and methods of scanning are described. An overview of the principles of foveal analysis, the prototype experimental system and initial results are presented

Uncovering the expression patterns of chimeric transcripts using surveys of affymetrix GeneChips.

BACKGROUND: A chimeric transcript is a single RNA sequence which results from the transcription of two adjacent genes. Recent studies estimate that at least 4% of tandem human gene pairs may form chimeric transcripts. Affymetrix GeneChip data are used to study the expression patterns of tens of thousands of genes and the probe sequences used in these microarrays can potentially map to exotic RNA sequences such as chimeras. RESULTS: We have studied human chimeras and investigated their expression patterns using large surveys of Affymetrix microarray data obtained from the Gene Expression Omnibus. We show that for six probe sets, a unique probe mapping to a transcript produced by one of the adjacent genes can be used to identify the expression patterns of readthrough transcripts. Furthermore, unique probes mapping to an intergenic exon present only in the MASK-BP3 chimera can be used directly to study the expression levels of this transcript. CONCLUSIONS: We have attempted to implement a new method for identifying tandem chimerism. In this analysis unambiguous probes are needed to measure run-off transcription and probes that map to intergenic exons are particularly valuable for identifying the expression of chimeras

Spin-Orbit Coupling and Ion Displacements in Multiferroic TbMnO3

The electronic and magnetic properties of TbMnO3 leading to its ferroelectric (FE) polarization were investigated on the basis of relativistic density functional theory (DFT) calculations. In agreement with experiment, we show that the spin-spiral plane of TbMnO3 can be either the bc- or ab-plane, but not the ac-plane. As for the mechanism of FE polarization, our work reveals that the "pure electronic" model by Katsura, Nagaosa and Balatsky (KNB) is inadequate in predicting the absolute direction of FE polarization. For the ab-plane spin-spiral state of TbMnO3, the direction of FE polarization predicted by the KNB model is opposite to that predicted by DFT calculations. In determining the magnitude and the absolute direction of FE polarization in spin-spiral states, it is found crucial to consider the displacements of the ions from their ecntrosymmetric positions

Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy

The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at tyrosine 701 and serine 727 where they translocate to the nucleus to regulate gene expression. STAT1 has been shown to be involved in promoting apoptotic cell death in response to cardiac ischemia/reperfusion and has recently been shown by our laboratory to be involved in negatively regulating autophagy. These processes are thought to promote cell death and restrict cell survival leading to the generation of an infarct. Here we present data that shows STAT1 localizes to the mitochondria and co-immunoprecipitates with LC3. Furthermore, electron microscopy studies also reveal mitochondria from ex vivo I/R treated hearts of STAT1KO mice contained within a double membrane autophagosome indicating that STAT1 may be involved in negatively regulating mitophagy. This is the first description of STAT1 being localized to the mitochondria and also having a role in mitophagy

Social Media as a Supplement to Face-to-Face Education: The Perspectives of Expanded Food and Nutrition Education Program Paraprofessionals and Graduates

Using social media is an inexpensive, innovative approach to supplementing direct education provided by the Expanded Food and Nutrition Education Program (EFNEP). Focus group research was conducted with EFNEP paraprofessionals (n = 33) and participants (n = 39) to inform the development of a social media presence for the program. Although recommendations by EFNEP\u27s social media committee focus on providing online articles, focus group results suggest that content should be presented as colorful pictures and videos, portraying recipes and nutrition tips. Also, the study highlights the importance of using engaging, colorful visuals when using social media as a form of indirect education

GRAMÁTICA TRADICIONAL E LÍNGUA ESCRITA: DUAS FACES DO MESMO PODER

RESUMO: Neste artigo, são analisadas as causas do fracasso do ensino de Língua Portuguesa na escola. O ponto a ser discutido é aquele que restringe o ensino apenas à modalidade escrita, tendo em vista que as sociedades se comunicam em vários modos semióticos. Para chegar a essa conclusão, remonta-se à Antiguidade Clássica, berço do surgimento da gramática tradicional, época em que a modalidade escrita produzida pelas elites passou a ser norma de todos. Depois, será analisado como se situou essa prática na Península Ibérica e no Brasil, desde a colônia até os dias atuais. O surgimento da Lingüística, as teorias do Letramento e dos Gêneros Discursivos, as áreas de discurso baseadas nos gêneros orais e escritos e as mudanças para o ensino abalaram as bases da gramática tradicional. PALAVRAS-CHAVE: Ensino de Língua Portuguesa. Gramática tradicional. Gêneros discursivos. Letramento. Legislação